Contextualizing single‐arm trials with real‐world data: An emulated target trial comparing therapies for neovascular age‐related macular degeneration

ABSTRACT: One‐in‐four ophthalmology trials are single‐armed, which poses challenges to their interpretation. We demonstrate how real‐world cohorts used as external/synthetic control arms can contextualize such trials. We herein emulated a target trial on the intention‐to‐treat efficacy of off‐label...

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Библиографические подробности
Опубликовано в: :Clin Transl Sci
Главные авторы: Thomas, Darren S., Lee, Aaron Y., Müller, Philipp L., Schwartz, Roy, Olvera‐Barrios, Abraham, Warwick, Alasdair N., Patel, Praven J., Heeren, Tjebo F.C., Egan, Catherine, Taylor, Paul, Tufail, Adnan
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212729/
https://ncbi.nlm.nih.gov/pubmed/33421321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12974
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