A phase 2 trial of gemcitabine and docetaxel in patients with metastatic colorectal adenocarcinoma with methylated checkpoint with forkhead and ring finger domain promoter and/or microsatellite instability phenotype

ABSTRACT: We previously reported CHFR methylation in a subset of colorectal cancer (CRC; ∼30%) with high concordance with microsatellite instability (MSI). We also showed that CHFR methylation predicted for sensitivity to docetaxel, whereas the MSI‐high phenotypes were sensitive to gemcitabine. We h...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Baretti, Marina, Karunasena, Enusha, Zahurak, Marianna, Walker, Rosalind, Zhao, Yang, Pisanic, Thomas R., Wang, Tza‐Huei, Greten, Tim F., Duffy, Austin G., Gootjes, Elske, Meijer, Gerrit, Verheul, Henk M.W., Ahuja, Nita, Herman, James G., Azad, Nilofer S.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212722/
https://ncbi.nlm.nih.gov/pubmed/33811727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12960
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