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DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins

Due to their large size, charged surfaces, and environmental sensitivity, proteins do not naturally cross cell-membranes in intact form and, therefore, are difficult to deliver for both diagnostic and therapeutic purposes. Based upon the observation that clustered oligonucleotides can naturally enga...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Wang, Shunzhi, Chen, Yijing, Wang, Shuya, Li, Peng, Mirkin, Chad A., Farha, Omar K.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212418/
https://ncbi.nlm.nih.gov/pubmed/30669839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b12705
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