Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells

Epithelial-mesenchymal transition (EMT) in primary tumor cells is a key prerequisite for metastasis initiation. Statins, cholesterol-lowering drugs, can delay metastasis formation in vivo and attenuate the growth and proliferation of tumor cells in vitro. The latter effect is stronger in tumor cells...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Warita, Katsuhiko, Ishikawa, Takuro, Sugiura, Akihiro, Tashiro, Jiro, Shimakura, Hiroaki, Hosaka, Yoshinao Z., Ohta, Ken-ichi, Warita, Tomoko, Oltvai, Zoltán N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211663/
https://ncbi.nlm.nih.gov/pubmed/34140545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91928-3
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