In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

Clonal expansion of HIV-infected cells contributes to the long-term persistence of the HIV reservoir in ART-suppressed individuals. However, the contribution from cell clones that harbor inducible proviruses to plasma viremia is poorly understood. Here, we describe a single-cell approach to simultan...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Cole, Basiel, Lambrechts, Laurens, Gantner, Pierre, Noppe, Ytse, Bonine, Noah, Witkowski, Wojciech, Chen, Lennie, Palmer, Sarah, Mullins, James I., Chomont, Nicolas, Pardons, Marion, Vandekerckhove, Linos
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211655/
https://ncbi.nlm.nih.gov/pubmed/34140517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24080-1
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