Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system

INTRODUCTION: Sickle cell disease (SCD) is a monogenic disease and it is estimated that 300,000 infants are born annually with it. Most treatments available are only palliative, whereas the allogeneic hematopoietic stem cell transplantation offers the only potential cure for SCD. OBJECTIVE: Generati...

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Detalhes bibliográficos
Publicado no:Hematol Transfus Cell Ther
Main Authors: Paes, Bárbara C.M.F., Stabeli, Luiza C.J.R., Costa, Péricles N.M., Orellana, Maristela Delgado, Kashima, Simone, Covas, Dimas Tadeu, Picanço-Castro, Virgínia
Formato: Artigo
Idioma:Inglês
Publicado em: Sociedade Brasileira de Hematologia e Hemoterapia 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211631/
https://ncbi.nlm.nih.gov/pubmed/32229108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.htct.2020.01.005
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