Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L

Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor control after radiotherapy depends on the eradication of cancer stem cells (CSCs) with activated DNA repair. This study provides evidence that the...

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Udgivet i:Oncogene
Main Authors: Nathansen, Jacqueline, Lukiyanchuk, Vasyl, Hein, Linda, Stolte, Maya-Isabel, Borgmann, Kerstin, Löck, Steffen, Kurth, Ina, Baumann, Michael, Krause, Mechthild, Linge, Annett, Dubrovska, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211562/
https://ncbi.nlm.nih.gov/pubmed/34079088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01842-1
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