Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase

Cytochrome P450s (CYPs) are an essential family of enzymes in the human body. They play a crucial role in metabolism, especially in human steroid biosynthesis. Reactions catalyzed by these enzymes are highly stereo- and regio-specific. Lack or severe malfunctions of CYPs can cause severe diseases an...

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Detalles Bibliográficos
Publicado en:Front Endocrinol (Lausanne)
Main Authors: Loke, Steffen, Stoll, Anna, Machalz, David, Botrè, Francesco, Wolber, Gerhard, Bureik, Matthias, Parr, Maria Kristina
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Endocrinology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211424/
https://ncbi.nlm.nih.gov/pubmed/34149610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2021.633785
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