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Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment

BACKGROUND: The temporal response to checkpoint blockade (CB) is incompletely understood. Here, we profiled the tumor infiltrating lymphocyte (TIL) landscape in response to combination checkpoint blockade at two distinct timepoints of solid tumor growth. METHODS: C57BL/6 mice bearing subcutaneous MC...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Aoyama, Shota, Nakagawa, Ryosuke, Nemoto, Satoshi, Perez-Villarroel, Patricio, Mulé, James J, Mailloux, Adam William
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211075/
https://ncbi.nlm.nih.gov/pubmed/34135102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002269
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