Pharmacogenetics to Avoid Loss of Hearing (PALOH) trial: a protocol for a prospective observational implementation trial

INTRODUCTION: In conjunction with a beta-lactam, aminoglycosides are the first-choice antibiotic for empirical treatment of sepsis in the neonatal period. The m.1555A>G variant predisposes to ototoxicity after aminoglycoside administration and has a prevalence of 1 in 500. Current genetic testing...

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Veröffentlicht in:BMJ Open
Hauptverfasser: McDermott, John Henry, Mahood, Rachel, Stoddard, Duncan, Mahaveer, Ajit, Turner, Mark A, Corry, Rachel, Garlick, Julia, Miele, Gino, Ainsworth, Shaun, Kemp, Laura, Bruce, Iain, Body, Richard, Ulph, Fiona, Macleod, Rhona, Harvey, Karen, Booth, Nicola, Roberts, Peter, Wilson, Paul, Newman, William G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Genetics and Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211036/
https://ncbi.nlm.nih.gov/pubmed/34135034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2020-044457
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