EGFR-targeted intraoperative fluorescence imaging detects high-grade glioma with panitumumab-IRDye800 in a phase 1 clinical trial

Rationale: First-line therapy for high-grade gliomas (HGGs) includes maximal safe surgical resection. The extent of resection predicts overall survival, but current neuroimaging approaches lack tumor specificity. The epidermal growth factor receptor (EGFR) is a highly expressed HGG biomarker. We eva...

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Pubblicato in:Theranostics
Autori principali: Zhou, Quan, van den Berg, Nynke S., Rosenthal, Eben L., Iv, Michael, Zhang, Michael, Vega Leonel, Johana C. M., Walters, Shannon, Nishio, Naoki, Granucci, Monica, Raymundo, Roan, Yi, Grace, Vogel, Hannes, Cayrol, Romain, Lee, Yu-Jin, Lu, Guolan, Hom, Marisa, Kang, Wenying, Hayden Gephart, Melanie, Recht, Larry, Nagpal, Seema, Thomas, Reena, Patel, Chirag, Grant, Gerald A., Li, Gordon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2021
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210618/
https://ncbi.nlm.nih.gov/pubmed/34158840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.60582
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