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CDK12: cellular functions and therapeutic potential of versatile player in cancer
Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain of RNA polymerase II and is needed for the optimal transcription elongation and translation of a subset of human protein-coding genes. The kinase has a pleiotropic effect on the maintenance of genome stability, and its inactivat...
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| Published in: | NAR Cancer |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8210036/ https://ncbi.nlm.nih.gov/pubmed/34316683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa003 |
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