Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator

Positive results in pre-clinical studies of the triple combination of elexacaftor, tezacaftor and ivacaftor, performed in airway epithelial cell cultures obtained from patients harbouring the class II cystic fibrosis transmembrane conductance regulator (CFTR) mutation F508del-CFTR, translated to imp...

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Detalhes bibliográficos
Publicado no:Eur Respir J
Main Authors: Laselva, Onofrio, Bartlett, Claire, Gunawardena, Tarini N.A., Ouyang, Hong, Eckford, Paul D.W., Moraes, Theo J., Bear, Christine E., Gonska, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: European Respiratory Society 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209484/
https://ncbi.nlm.nih.gov/pubmed/33303536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02774-2020
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