3,3’-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer

Paclitaxel (PTX) is a first-line chemotherapeutic drug for the treatment of breast cancer, but drug resistance seriously limits its clinical use. The aim of the present work was to explore the effect of 3,3’-diindolylmethane (DIM) on PTX sensitivity and its possible mechanism in breast cancer. The e...

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Publicat a:Front Oncol
Autors principals: Xiang, Fenfen, Zhu, Zhaowei, Zhang, Mengzhe, Wang, Jie, Chen, Zixi, Li, Xiaoxiao, Zhang, Tao, Gu, Qing, Wu, Rong, Kang, Xiangdong
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209418/
https://ncbi.nlm.nih.gov/pubmed/34150611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.627856
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