Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas

Supplementation of cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA) with high concentration pyridoxal 5′-phosphate, the cofactor of vitamin B6, potentiates the cytotoxicity of FUra in a synergistic interaction mode. We report a pilot study in 13 patients with previously untreated...

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Udgivet i:Sci Rep
Main Authors: Machover, David, Almohamad, Wathek, Castagné, Vincent, Desterke, Christophe, Gomez, Léa, Gaston-Mathé, Yann, Boucheix, Claude, Goldschmidt, Emma
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8209008/
https://ncbi.nlm.nih.gov/pubmed/34135415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92110-5
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