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Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure

BACKGROUND: The treatment of periprosthetic joint infection (PJI) is focused on the surgical or chemical removal of biofilm. Antibiotics in isolation are typically ineffective against PJI. Bacteria survive after antibiotic administration because of antibiotic tolerance, resistance, and persistence t...

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Detalles Bibliográficos
Publicado en:Clin Orthop Relat Res
Main Authors: Manasherob, Robert, Mooney, Jake A., Lowenberg, David W., Bollyky, Paul L., Amanatullah, Derek F.
Formato: Artigo
Idioma:Inglês
Publicado: Wolters Kluwer 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208434/
https://ncbi.nlm.nih.gov/pubmed/33835090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CORR.0000000000001740
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