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DeepFrag: a deep convolutional neural network for fragment-based lead optimization

Machine learning has been increasingly applied to the field of computer-aided drug discovery in recent years, leading to notable advances in binding-affinity prediction, virtual screening, and QSAR. Surprisingly, it is less often applied to lead optimization, the process of identifying chemical frag...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Green, Harrison, Koes, David R., Durrant, Jacob D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208308/
https://ncbi.nlm.nih.gov/pubmed/34194693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00163a
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