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Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction

We have previously identified that human Ku70, a nuclear protein, serves as a cytosolic DNA sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the nucleus into the cytoplasm and then predominately induces interferon lambda1 (IFN‐λ1) rather than IFN‐alpha or IFN‐be...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Sui, Hongyan, Chen, Qian, Imamichi, Tomozumi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8207419/
https://ncbi.nlm.nih.gov/pubmed/33548066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13318
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