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Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

Non-additive genetic variance for complex traits is traditionally estimated from data on relatives. It is notoriously difficult to estimate without bias in non-laboratory species, including humans, because of possible confounding with environmental covariance among relatives. In principle, non-addit...

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Bibliografiska uppgifter
I publikationen:Am J Hum Genet
Huvudupphovsmän: Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic, Visscher, Peter M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205999/
https://ncbi.nlm.nih.gov/pubmed/33811805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.02.014
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