Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellula...

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Udgivet i:Drug Deliv
Main Authors: Hendel, Kristoffer, Hansen, Anders C. N., Bik, Liora, Bagger, Charlotte, van Doorn, Martijn B. A., Janfelt, Christian, Olesen, Uffe H., Haedersdal, Merete, Lerche, Catharina M.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205002/
https://ncbi.nlm.nih.gov/pubmed/34121567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1933649
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