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Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir
[Image: see text] SARS-CoV-2 main protease (M(pro)) is a cysteine protease that mediates the cleavage of viral polyproteins and is a validated antiviral drug target. M(pro) is highly conserved among all seven human coronaviruses, with certain M(pro) inhibitors having broad-spectrum antiviral activit...
Tallennettuna:
| Julkaisussa: | ACS Pharmacol Transl Sci |
|---|---|
| Päätekijät: | , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American
Chemical Society
2021
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| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8204911/ https://ncbi.nlm.nih.gov/pubmed/34414360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00099 |
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