MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats

A previous study from our team found that hyperbaric oxygen (HBO) pretreatment attenuated decompression sickness (DCS) spinal cord injury by upregulating heat shock protein 32 (HSP32) via the ROS/p38 MAPK pathway. Meanwhile, a MEK1/2-negative regulatory pathway was also activated to inhibit HSP32 ov...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Zhou, Quan, Meng, Xiangyang, Huang, Guoyang, Yi, Hongjie, Zheng, Juan, Zhang, Kun, Xu, Weigang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204088/
https://ncbi.nlm.nih.gov/pubmed/34140895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.674430
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