Eruptive xanthoma model reveals endothelial cells internalize and metabolize chylomicrons, leading to extravascular triglyceride accumulation

Although tissue uptake of fatty acids from chylomicrons is primarily via lipoprotein lipase (LpL) hydrolysis of triglycerides (TGs), studies of patients with genetic LpL deficiency suggest additional pathways deliver dietary lipids to tissues. Despite an intact endothelial cell (EC) barrier, hyperch...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cabodevilla, Ainara G., Tang, Songtao, Lee, Sungwoon, Mullick, Adam E., Aleman, Jose O., Hussain, M. Mahmood, Sessa, William C., Abumrad, Nada A., Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203467/
https://ncbi.nlm.nih.gov/pubmed/34128469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI145800
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