Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes

BACKGROUND: The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of β cell mass. There is a long-standing debate as to the relative contribution of these factors to clinically manifesting β cell dysfunction. The aim of this st...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Moffa, Simona, Cefalo, Chiara M.A., Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203447/
https://ncbi.nlm.nih.gov/pubmed/33905373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146788
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