NDRG1 facilitates lytic replication of Kaposi’s sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase

The presumed DNA helicase encoded by ORF44 of Kaposi’s sarcoma-associated herpesvirus (KSHV) plays a crucial role in unwinding viral double-stranded DNA and initiating DNA replication during lytic reactivation. However, the regulatory mechanism of KSHV ORF44 has not been fully elucidated. In a previ...

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Vydáno v:PLoS Pathog
Hlavní autoři: Dong, Lianghui, Dong, Jiazhen, Xiang, Min, Lei, Ping, Li, Zixian, Zhang, Fang, Sun, Xiaoyi, Niu, Danping, Bai, Lei, Lan, Ke
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202935/
https://ncbi.nlm.nih.gov/pubmed/34077484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009645
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