κ-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling

In the present study, the effects and mechanism of action of U50,488H (a selective κ-opioid receptor agonist) on calcification of rat vascular smooth muscle cells (VSMCs) induced by β-glycerophosphate (β-GP) were investigated. VSMCs were isolated and cultured in traditional FBS-based media. A calcif...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Niu, Jin, Wu, Chen, Zhang, Min, Yang, Zhen, Liu, Zhenhua, Fu, Feng, Li, Jun, Feng, Na, Gu, Xiaoming, Zhang, Shumiao, Liu, Yali, Fan, Rong, Li, Juan, Pei, Jianming
Format: Artigo
Language:Inglês
Published: Impact Journals 2021
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202865/
https://ncbi.nlm.nih.gov/pubmed/34016793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.203050
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