Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity

Autophagy is a highly conserved degradative pathway, essential for cellular homeostasis and implicated in diseases including cancer and neurodegeneration. Autophagy-related 8 (ATG8) proteins play a central role in autophagosome formation and selective delivery of cytoplasmic cargo to lysosomes by re...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Wirth, Martina, Mouilleron, Stephane, Zhang, Wenxin, Sjøttem, Eva, Princely Abudu, Yakubu, Jain, Ashish, Lauritz Olsvik, Hallvard, Bruun, Jack-Ansgar, Razi, Minoo, Jefferies, Harold B.J., Lee, Rebecca, Joshi, Dhira, O'Reilly, Nicola, Johansen, Terje, Tooze, Sharon A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202330/
https://ncbi.nlm.nih.gov/pubmed/33845085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166987
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