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Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal–CA1 projection
BACKGROUND: Memantine, a low- to moderate-affinity uncompetitive N-methyl-D-aspartate receptor antagonist, has been shown to improve cognitive functions in animal models of Alzheimer’s disease (AD). Here we treated APP/PS1 AD mice with a therapeutic dose of memantine (20 mg/kg/day) and examined its...
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| Publicado no: | BMC Neurosci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8201811/ https://ncbi.nlm.nih.gov/pubmed/34120588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-021-00647-y |
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