Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential (TRP) channels, purinergic receptor (P2Y), and mitogen-activated protein kinase (MAPK) signaling play a crucial role in...

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Publicat a:Int J Mol Sci
Autors principals: Khan, Adnan, Shal, Bushra, Khan, Ashraf Ullah, Ullah, Rahim, Baig, Muhammad Waleed, ul Haq, Ihsan, Seo, Eun Kyoung, Khan, Salman
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8200233/
https://ncbi.nlm.nih.gov/pubmed/34199936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22116084
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