In Vitro and In Vivo Activity of 14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] Mutilin against Methicillin-Resistant Staphylococcus aureus

Staphylococcus aureus (S. aureus) is a major human pathogen that requires new antibiotics with unique mechanism. A new pleuromutilin derivative, 14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] mutilin (DPTM), has been synthesized and proved as a potent antibacterial agent using in vitro and in vivo...

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Vydáno v:Molecules
Hlavní autoři: Fu, Yunxing, Leng, Chunqing, Fan, Yuan, Ma, Xia, Li, Xianghui, Wang, Xuefei, Guo, Zhenghuan, Wang, Xiujun, Shang, Ruofeng
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199141/
https://ncbi.nlm.nih.gov/pubmed/34071703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26113277
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