Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioisomers for Antimalarial, Antiproliferative and Antimicrobial Activities

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher s...

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Veröffentlicht in:Molecules
Hauptverfasser: Håheim, Katja S., Lindbäck, Emil, Tan, Kah Ni, Albrigtsen, Marte, Urdal Helgeland, Ida T., Lauga, Clémence, Matringe, Théodora, Kennedy, Emily K., Andersen, Jeanette H., Avery, Vicky M., Sydnes, Magne O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8198049/
https://ncbi.nlm.nih.gov/pubmed/34070798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26113268
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