P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice

Non-alcoholic fatty liver disease (NAFLD) is a chronic metabolic liver disease associated with obesity and insulin resistance. Activation of the purinergic receptor P2Y2R has been reported to promote adipogenesis, inflammation and dyslipidemia in adipose tissues in obese mice. However, the role of P...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Dusabimana, Theodomir, Park, Eun Jung, Je, Jihyun, Jeong, Kyuho, Yun, Seung Pil, Kim, Hye Jung, Kim, Hwajin, Park, Sang Won
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197197/
https://ncbi.nlm.nih.gov/pubmed/34073834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115528
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