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Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains
Cyclic AMP (cAMP)-dependent signaling is highly implicated in the pathophysiology of alcohol use disorder (AUD), with evidence supporting the efficacy of inhibiting the cAMP hydrolyzing enzyme phosphodiesterase 4 (PDE4) as a therapeutic strategy for drinking reduction. Off-target emetic effects asso...
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| Publicado no: | Int J Mol Sci |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8196757/ https://ncbi.nlm.nih.gov/pubmed/34064099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22115443 |
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