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Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells

Bone marrow (BM) chimeric mice are a valuable tool in the field of immunology, with the genetic manipulation of donor cells widely used to study gene function under physiological and pathological settings. To date, however, BM chimera protocols require myeloablative conditioning of recipient mice, w...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ochi, Kiyosumi, Morita, Maiko, Wilkinson, Adam C., Iwama, Atsushi, Yamazaki, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195984/
https://ncbi.nlm.nih.gov/pubmed/34117255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23763-z
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