The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy

5-Fluorouracil (5-FU)-based chemotherapy is the first-line treatment for colorectal cancer (CRC) but is hampered by chemoresistance. Despite its impact on patient survival, the mechanism underlying chemoresistance against 5-FU remains poorly understood. Here, we identified serine hydroxymethyltransf...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Chen, Jian, Na, Risi, Xiao, Chao, Wang, Xiao, Wang, Yupeng, Yan, Dongwang, Song, Guohe, Liu, Xueni, Chen, Jiayi, Lu, Huijun, Chen, Chunyan, Tang, Huamei, Zhuang, Guohong, Fan, Guangjian, Peng, Zhihai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195740/
https://ncbi.nlm.nih.gov/pubmed/33990700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01815-4
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