Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling

Avasimibe is a bioavailable acetyl-CoA acetyltransferase (ACAT) inhibitor and shows a good antitumor effect in various human solid tumors, but its therapeutic value in cholangiocarcinoma (CCA) and underlying mechanisms are largely unknown. In the study, we proved that avasimibe retard cell prolifera...

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Bibliografiske detaljer
Udgivet i:Front Oncol
Main Authors: Gao, Yunshu, Xu, Dongyun, Li, Hongwei, Xu, Jiahua, Pan, Yating, Liao, Xinyi, Qian, Jianxin, Hu, Yi, Yu, Guanzhen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195695/
https://ncbi.nlm.nih.gov/pubmed/34127944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.677678
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