High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics

Currently, high-throughput approaches are lacking in the isolation of antibodies with functional readouts beyond simple binding. This situation has impeded the next generation of cancer immunotherapeutics, such as bispecific T cell engager (BiTE) antibodies or agonist antibodies against costimulator...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Wang, Yuan, Jin, Ruina, Shen, Bingqing, Li, Na, Zhou, He, Wang, Wei, Zhao, Yingjie, Huang, Mengshi, Fang, Pan, Wang, Shanshan, Mary, Pascaline, Wang, Ruikun, Ma, Peixiang, Li, Ruonan, Tian, Yujie, Cao, Youjia, Li, Fubin, Schweizer, Liang, Zhang, Hongkai
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195480/
https://ncbi.nlm.nih.gov/pubmed/34117053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe3839
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