Pharmacokinetic Characteristics, Tissue Bioaccumulation and Toxicity Profiles of Oral Arsenic Trioxide in Rats: Implications for the Treatment and Risk Assessment of Acute Promyelocytic Leukemia

Oral arsenic trioxide (ATO) has demonstrated a favorable clinical efficiency in the treatment of acute promyelocytic leukemia (APL). However, the pharmacokinetic characteristics, tissue bioaccumulation, and toxicity profiles of arsenic metabolites in vivo following oral administration of ATO have no...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Wensheng, Wang, Bin, Zhao, Yilei, Wu, Zhiqiang, Dong, Andi, Chen, Hongzhu, Lin, Liwang, Lu, Jing, Hai, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8194082/
https://ncbi.nlm.nih.gov/pubmed/34122070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.647687
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