Notch inhibitors induce diarrhea, hypercrinia and secretory cell metaplasia in the human colon

In humans, inhibition of Notch oncogenic signaling leads to tumor regression. Preclinical studies indicate that Notch signaling contributes to the maintenance of intestinal homeostasis. Here, we sought to describe the intestinal effects of a first-in-human Notch inhibitor in an indication of refract...

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Detalhes bibliográficos
Publicado no:EXCLI J
Main Authors: Collins, Michael, Michot, Jean-Marie, Bellanger, Christophe, Mussini, Charlotte, Benhadji, Karim, Massard, Christophe, Carbonnel, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: Leibniz Research Centre for Working Environment and Human Factors 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192874/
https://ncbi.nlm.nih.gov/pubmed/34121974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2021-3572
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