Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. This differentiation block has been linked to dysregulation of multiple cellular processes, including transcriptional, chromatin, and metabolic...

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Publicado no:iScience
Main Authors: Zee, Barry M., Poels, Kamrine E., Yao, Cong-Hui, Kawabata, Kimihito C., Wu, Gongwei, Duy, Cihangir, Jacobus, William D., Senior, Elizabeth, Endress, Jennifer E., Jambhekar, Ashwini, Lovitch, Scott B., Ma, Jiexian, Dhall, Abhinav, Harris, Isaac S., Blanco, M. Andres, Sykes, David B., Licht, Jonathan D., Weinstock, David M., Melnick, Ari, Haigis, Marcia C., Michor, Franziska, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192696/
https://ncbi.nlm.nih.gov/pubmed/34151238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102651
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