Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or gener...

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Udgivet i:Sci Rep
Main Authors: Le, Brian L., Andreoletti, Gaia, Oskotsky, Tomiko, Vallejo-Gracia, Albert, Rosales, Romel, Yu, Katharine, Kosti, Idit, Leon, Kristoffer E., Bunis, Daniel G., Li, Christine, Kumar, G. Renuka, White, Kris M., García-Sastre, Adolfo, Ott, Melanie, Sirota, Marina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192542/
https://ncbi.nlm.nih.gov/pubmed/34112877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91625-1
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