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Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones
8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-d-ribose-2′-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen Mycobacter...
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| Publicado no: | Med Chem Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8192043/ https://ncbi.nlm.nih.gov/pubmed/34131377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-021-02735-4 |
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