Cytoplasmic RRM1 activation as an acute response to gemcitabine treatment is involved in drug resistance of pancreatic cancer cells

BACKGROUND: RRM1 is functionally associated with DNA replication and DNA damage repair. However, the biological activity of RRM1 in pancreatic cancer remains undetermined. METHODS: To determine relationships between RRM1 expression and the prognosis of pancreatic cancer, and to explore RRM1 function...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Kato, Tomotaka, Ono, Hiroaki, Fujii, Mikiya, Akahoshi, Keiichi, Ogura, Toshiro, Ogawa, Kosuke, Ban, Daisuke, Kudo, Atsushi, Tanaka, Shinji, Tanabe, Minoru
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191885/
https://ncbi.nlm.nih.gov/pubmed/34111175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0252917
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