Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants

Allogeneic islet transplantation is a promising cell-based therapy for Type 1 Diabetes (T1D). The long-term efficacy of this approach, however, is impaired by allorejection. Current clinical practice relies on long-term systemic immunosuppression, leading to severe adverse events. To avoid these det...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Li, Ying, Frei, Anthony W., Labrada, Irayme M., Rong, Yanan, Liang, Jia-Pu, Samojlik, Magdalena M., Sun, Chuqiao, Barash, Steven, Keselowsky, Benjamin G., Bayer, Allison L., Stabler, Cherie L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190479/
https://ncbi.nlm.nih.gov/pubmed/34122410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.653088
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