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Mutation load decreases with haplotype age in wild Soay sheep

Runs of homozygosity (ROH) are pervasive in diploid genomes and expose the effects of deleterious recessive mutations, but how exactly these regions contribute to variation in fitness remains unclear. Here, we combined empirical analyses and simulations to explore the deleterious effects of ROH with...

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Pubblicato in:Evol Lett
Autori principali: Stoffel, Martin A., Johnston, Susan E., Pilkington, Jill G., Pemberton, Josephine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190445/
https://ncbi.nlm.nih.gov/pubmed/34136268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/evl3.229
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