T cell–depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution

Human age-related thymus involution is characterized by loss of developing thymocytes and the thymic epithelial network that supports them, with replacement by adipose tissue. The mechanisms that drive these changes are difficult to study in vivo due to constant trafficking to and from the thymus. W...

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Bibliographic Details
Published in:GeroScience
Main Authors: Hale, Laura P., Cheatham, Lynn, Macintyre, Andrew N., LaFleur, Bonnie, Sanders, Brittany, Troy, Jesse, Kurtzberg, Joanne, Sempowski, Gregory D.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190428/
https://ncbi.nlm.nih.gov/pubmed/33420705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00301-1
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