Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia

HI, a fusion protein that consists of the alpha-toxin (Hla) and the N2 domain of iron surface determinant B (IsdB), is one of the antigens in the previously reported S. aureus vaccine rFSAV and has already entered phase II clinical trials. Previous studies revealed that HI is highly immunogenic in b...

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Vydáno v:Front Immunol
Hlavní autoři: Chen, Zhifu, Gou, Qiang, Xiong, Qingshan, Duan, Lianli, Yuan, Yue, Zhu, Jiang, Zou, Jintao, Chen, Longlong, Jing, Haiming, Zhang, Xiaoli, Luo, Ping, Zeng, Hao, Zou, Quanming, Zhao, Zhuo, Zhang, Jinyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190387/
https://ncbi.nlm.nih.gov/pubmed/34122448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.684823
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