SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome—the Myhre syndrome

SMAD4 encodes a member of the SMAD family of proteins involved in the TGF-β signaling pathway. Potentially heritable, autosomal dominant, gain-of-function heterozygous variants of SMAD4 cause a rare developmental disorder, the Myhre syndrome, which is associated with a wide range of developmental an...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Kandhaya-Pillai, Renuka, Hou, Deyin, Zhang, Jiaming, Yang, Xiaomeng, Compoginis, Goli, Mori, Takayasu, Tchkonia, Tamara, Martin, George M., Hisama, Fuki M., Kirkland, James L., Oshima, Junko
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190230/
https://ncbi.nlm.nih.gov/pubmed/33428109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00318-6
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