Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures

Undifferentiated pleomorphic sarcoma (UPS), an aggressive soft-tissue sarcoma of adults, has been characterized by low tumor mutational burden (TMB) and high copy number alterations. Clinical trials of programmed death-1 (PD-1) blockade in UPS have reported widely varying efficacy. We describe two p...

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Gepubliceerd in:J Immunother Cancer
Hoofdauteurs: Cheung, Laurene S, Chen, Lingling, Oke, Teniola F, Schaffer, Thomas B, Boudadi, Karim, Ngo, Jillian T, Gross, John McMahon, Kemberling, Holly, Diaz, Luis A, Lipson, Evan, Sidhom, John-WIlliam, Taube, Janis, Anders, Robert, Pardoll, Drew M, Le, Dung T, Meyer, Christian F, Llosa, Nicolas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2021
Onderwerpen:
Case Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190056/
https://ncbi.nlm.nih.gov/pubmed/34103354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002345
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