Capsule and Sprinkle Formulations of Lubiprostone Are Not Biologically Similar in Patients with Functional Constipation

INTRODUCTION: Lubiprostone capsules are approved for managing three different chronic constipation conditions. A “sprinkle” formulation may facilitate use in individuals with difficulty swallowing capsules. Our objective was to evaluate the bioequivalence, pharmacokinetics (PK), and bioavailability...

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Опубликовано в: :Adv Ther
Главные авторы: Adams, Atoya, Barish, Charles, Chen, Angel, Dennis, Patrick, Krause, Richard, Lichtlen, Peter, Losch-Beridon, Taryn, Mareya, Shadreck, Schneider, Jeffrey
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Healthcare 2021
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190023/
https://ncbi.nlm.nih.gov/pubmed/33834354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12325-021-01707-9
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